TB-500 (Thymosin Beta 4) 5mg

TB-500 is a synthetic variant of the naturally occurring peptide Thymosin Beta 4 (TB-500), found in nearly all human and animal cells. It is recognized as a first-in-class drug candidate that facilitates the following:

    Differentiation of endothelial (blood vessel) cells
    Angiogenesis (formation of new blood vessels from existing ones) in dermal tissues
    Migration of keratinocytes
    Deposition of collagen; and
    Reduction in inflammation.

A primary mechanism by which TB-500 functions is through the regulation of Actin, a critical cell-building protein essential for cell structure and movement. Among the multitude of proteins within cells, actin constitutes up to 10% of the total protein mass, thus playing a significant role in the cell's genetic makeup.

This powerful peptide belongs to a widespread family of 16 related molecules, exhibiting high sequence conservation and presence in most body tissues and circulating cells. TB-500 not only interacts with actin but also inhibits actin polymerization, acting as the actin-sequestering molecule in eukaryotic cells.

TB-500 was discovered as a gene that is up-regulated four to six times during the initial stages of blood vessel formation and is shown to support the growth of new blood cells from existing vessels. It can be found in wound fluid and, when injected subcutaneously, enhances wound healing, muscle development, and accelerates the recovery of muscle fibers and their associated cells.

A further significant aspect of TB-500 is its ability to encourage cell migration through specific interactions with actin within the cell cytoskeleton. Research has demonstrated that a central, small amino acid long actin binding domain exhibits both characteristics of blood cell reproduction and wound healing. These properties are revealed by stimulating the migration of endothelial cells and keratinocytes, as well as boosting the production of enzymes that degrade the extracellular matrix.

Studies confirm that TB-500 is a strong, naturally occurring wound repair factor with anti-inflammatory effects. Unlike other repair factors, such as growth factors, TB-500 promotes the migration of endothelial and keratinocyte cells. It also has a minimal tendency to bind to the extracellular matrix and possesses a low molecular weight, allowing it to traverse relatively long distances within tissues.